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. Author manuscript; available in PMC: 2017 Jul 9.
Published in final edited form as: Brain Behav Immun. 2015 Oct 19;55:70–81. doi: 10.1016/j.bbi.2015.10.006

Figure 6. Nerve injury induces spinal CX3CR1 expression in both sexes and spinal microglial p38 activation primarily in male mice 7 days post CCI.

Figure 6

(A, B) CX3CR1-GFP (green) and immunofluorescent staining of p-p38 (red) in dorsal horn sections from CX3CR1-GFP mice of a male (A) and a female (B) 7 days post-CCI. GFP shows morphological activation and proliferation of microglia in the dorsal horn of both male and female mice. Note that p-p38 staining is colocalized with the microglial marker CX3CR1. Also note that p-p38 staining is stronger in male microglia. Scales, 50 μm (up panel in B) and 25 μm (low panel in B).