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. Author manuscript; available in PMC: 2017 Jul 9.
Published in final edited form as: Proteomics Clin Appl. 2015 Mar 19;9(3-4):358–367. doi: 10.1002/prca.201400114

Figure 2. Conventional versus EV-based methods for the discovery and validation of biomarkers.

Figure 2

Conventional method of biomarker discovery and validation via mass spectrometry and/or ELISA are challenged by high abundant proteins in bodily fluid samples thereby hindering the detection of biomarkers. In contrast, utilizing EVs decreases the complexity of the sample by depleting the high abundant proteins.