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Mucosal secretory responses. (A) Baseline duodenal short circuit current (Isc) of healthy and IBS-C participants. HV n=17, IBS-C n=17 (B) Duodenal ΔIsc in response to 0.0003M submucosal ACh. HV n=17, IBS-C n=18. Panels C (HV n=14, IBS-C n=12) and D (HV n=18, IBS-C n=17) are corresponding values for colonic mucosa.
