Table 1.
Trial | Drug | Primary endpoint |
PEP-CHF14 | ACEI | all cause death or HF hospitalization |
CHARM-Preserved16 | ARB | CV death or HF hospitalization |
I-Preserve15 | ARB | all cause death or CV hospitalization |
TOP-CAT26 | MRB | CV death, aborted cardiac arrest, or HF hospitalization |
J-DHF34 | β-blocker | CV death and HF hospitalization |
DIG ancillary46 | Digitalis | HF mortality or HF hospitalization |
ACEI, angiotensin converting enzyme inhibitor; ARB, angiotensin receptor blocker; CV, cardiovascular; HF, heart failure; MRB, mineralocorticoid receptor blocker.