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. 2017 Jun 26;60(2):71–76.

Table 1.

Clinical trials to investigate the effects of pharmacological intervention on clinical outcomes of HFpEF

Trial Drug Primary endpoint
PEP-CHF14 ACEI all cause death or HF hospitalization
CHARM-Preserved16 ARB CV death or HF hospitalization
I-Preserve15 ARB all cause death or CV hospitalization
TOP-CAT26 MRB CV death, aborted cardiac arrest, or HF hospitalization
J-DHF34 β-blocker CV death and HF hospitalization
DIG ancillary46 Digitalis HF mortality or HF hospitalization

ACEI, angiotensin converting enzyme inhibitor; ARB, angiotensin receptor blocker; CV, cardiovascular; HF, heart failure; MRB, mineralocorticoid receptor blocker.