Table 2.

Toxicity profile

	S-1 + vaccine					S-1
	n = 6					n = 8
	Grade					Grade
	1	2	3	4		1	2	3	4
Injection-site reaction	0	1	5	/		–	–	–	/
Leukopenia	0	1	0	0		0	0	0	0
Neutropenia	0	1	0	0		0	0	0	0
Diarrhea	2	1	0	0		2	2	0	0
Anorexia	1	1	0	0		2	2	0	0
Fatigue	0	1	0	0		0	1	0	0
Stomatitis	1	0	0	0		1	1	0	0
Increase in AST/ALT	0	0	0	0		0	0	0	0
Increase in creatine	0	0	0	0		0	0	0	0
Fever	0	0	0	0		0	0	0	0
Flu-like symptoms	0	0	0	0		1	0	0	0

ALT, alanine aminotransferase; AST, aspartate aminotransferase.