Table 3.

Multivariate analysis of reasons for non-thrombolysis comparing the first (n=959) with the second (n=1060) half of the observation period

Patients (n=2019)	2003–2006	2006–2011	OR	p Value	95% CI
Too late intravenous and no indication intra-arterial	127 (13%)	76 (7%)	1.79*	0.010	1.15 to 2.78
Unknown onset	268 (28%)	399 (38%)	0.69*	0.008	0.53 to 0.91
Too mild stroke	442 (46%)	497 (47%)	0.66*	0.002	0.51 to 0.86
Too severe stroke	20 (2%)	5 (1%)	10.56*	0.029	1.28 to 87.42
Rapid improvement to below threshold	16 (2%)	2 (0.2%)	5.43	0.109	0.69 to 43.01
Age >80 years	183 (19%)	102 (10%)	2.65*	0.000	1.76 to 3.99
Intracranial haemorrhage	3 (0.3%)	20 (2%)	0.11*	0.004	0.02 to 0.50
Other bleeding reasons	3 (0.3%)	21 (2%)	0.18*	0.020	0.04 to 0.77
Stroke uncertain	10 (1%)	48 (5%)	0.19*	0.000	0.08 to 0.44
Comorbidity/dependency	21 (2%)	64 (6%)	0.16*	0.000	0.09 to 0.31
Diabetes mellitus	132 (14%)	200 (19%)	0.53*	0.000	0.39 to 0.72
Hyperlipidaemia	589 (61%)	707 (67%)	0.53*	0.000	0.40 to 0.70
Probable atherosclerotic stroke mechanism (<50% stenosis)	151 (16%)	152 (14%)	1.50*	0.023	1.06 to 2.11
Microangiopathic stroke mechanism	171 (18%)	149 (14%)	1.72*	0.002	1.21 to 2.43

OR >1 means more likely in first half and <1 means more likely in second half of observation period.

Asterisk (*), significant on p<0.05 level. Definitions of reasons for non-thrombolysis see text/table 5.