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. 2017 Jul 10;3:17034. doi: 10.1038/cddiscovery.2017.34

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Copyright © 2017 The Author(s)

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EGCG suppressed the ER stress-induced PERK signaling. (a) QGY-7703 or Hela cells were pre-treated with or without 100 μM EGCG for 2 h followed by UPR induction for 6 h. Cell lysates were resolved by SDS-PAGE and then immunoblotted with antibodies against p-PERK (Thr 981), p-eIF2α (Ser 51), eIF2α (total) and Tubulin. (b) Relative protein levels of p-PERK and p-eIF2α were normalized against tubulin by Image J Analysis Software and data were shown as means±S.D. for three independent experiments. *P<0.05, **P<0.01. BFA, Brefeldin A treated; p-PERK, phospho-PERK; p-eIF2α, phospho-eIF2α; TUN, Tunicamycin treated; UT, untreated.