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. Author manuscript; available in PMC: 2017 Jul 10.
Published in final edited form as: Biochemistry. 2016 Jan 13;55(3):510–518. doi: 10.1021/acs.biochem.5b01107

Figure-1.

Figure-1

(A) Comparison of the primary sequence of human IAPP and pufferfish IAPP. Residues which differ from the human peptide are colored red. Both sequences have amidated C-termini and contain a disulfide bond between residues 2 and 7. (B) Cross-section of a model of the human IAPP amyloid fibril based on crystal structures of fragments of the molecule. Residues in pufferfish IAPP which differ from the human sequence are built into the model and are shown in space filling format. (C) Ribbon diagram of the fibril.