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Phylogeny of P450 genes with insect orthologs. Neighbor-joining midpoint rooted tree of P450s from R. prolixus (red), A. pisum (green) and D. citri (blue) was generated using CLUSTAL Omega and drawn in Figtree. Four clans of P450s, CYP2 (orange), CYP3 (green), CYP4 (red) and mito (blue) clan are shown in the phylogenetic tree. Arc A, B and C are described in the main body of text. Excluding some partial genes, a total of 189 P450s were used to generate this phylogenetic tree.
