Fig. 2.

GW405833 dose dependently reversed PSNL-induced mechanical allodynia in both WT and CB₂KO mice (A). The effect of GW405833 (30 mg/kg i.p.) was only slightly attenuated by pretreatment with the CB₂ antagonist SR144528 (10 mg/kg i.p.). Mechanical thresholds were not changed in the contralateral paw after PSNL or by drug treatments (B). WT (C57BL/6J): n = 6 males; CB₂KO: n = 6 males. ^#P < 0.05 vs. baseline; *P < 0.05 vs. vehicle (0 mg/kg i.p.); ^P < 0.05 vs. GW405833 (3 mg/kg i.p.); ^&P < 0.05 vs. GW405833 (30 mg/kg i.p.) in WT. BL, preinjury baseline. SR2, CB₂ antagonist SR144528; ipsilateral, injured side; contralateral, uninjured side.