Fig. 7.

Mice develop behavioral tolerance to Δ⁹-THC administration. Δ⁹-THC (50 mg/kg i.p.) produces motor impairment (A), hypothermia (B), and antinociception (C) on day 1 of repeated dosing relative to baseline and day 8 of Δ⁹-THC administration (A–C), indicating that mice had become tolerant to the pharmacologic effects of Δ⁹-THC. Data are expressed as mean ± S.E.M. (n = 12 C57BL/6J male mice). **P < 0.01; ***P < 0.0001 vs. baseline or day 8; ^#P < 0.05; ^###P < 0.0001 vs. baseline, paired-samples t test.