Table 1.

A summary of candidate genes of human adaptation on pigmentation

Gene	SNP	Population	Skin color	Hair color	Eye color	References
APBA2	rs4424881		√			[68]
ASIP	rs6058017		√		√	[71, 72, 74, 118]
	rs4911442		√		√	[40, 118]
DCT	rs1325611		√			[49]
	rs1407995		√			[40, 49, 74]
	rs9516418		√			[49]
	rs3782974		√			[50]
	rs2031526		√			[38]
GRM5	rs10831469		√			[68]
HERC2	rs79097182			√		[60]
IRF4	rs12203592		√	√		[40, 118]
	rs1540771			√		[60, 118]
KITLG	rs1881227		√			[56, 119]
	rs642742		√			[61, 118]
	rs12821256			√		[40, 60, 118]
MC1R	rs885479		√	√		[40, 74, 118, 119]
	rs1805005		√	√		[29, 74, 118, 120]
	rs1805006		√	√		[74, 118]
	rs1805007		√	√		[57, 74, 118, 121]
	rs1805008		√	√		[57, 74, 118]
	rs1805009			√		[118]
	rs2228479		√	√		[74, 107, 118]
	rs2353688			√		[60]
	rs146972365			√		[60]
	rs8063160			√		[60]
	rs11547464		√		√	[118]
	rs1110400		√	√		[118]
OCA2	rs12913832		√		√	[23, 40, 68, 118]
	rs1800404		√			[48]
	rs1800407		√		√	[118]
	rs1800414		√		√	[40, 47, 50, 118, 122]
	rs74653330		√			[40, 48]
	rs150335311		√			[48]
	rs1448484		√			[50]
	rs1667394		√			[57]
SLC24A4	rs12896399		√	√	√	[57, 118]
	rs8014907			√		[60]
SLC24A5	rs1426654		√			[17, 23, 40, 61, 68, 72, 75, 118]
	rs2470102		√		√	[68]
SLC45A2	rs16891982		√			[17, 18, 21, 23, 27, 40, 50, 61, 112, 118]
	rs26722		√			[18, 27, 118]
	rs11568737		√			[48]
	rs35395		√			[68]
TPCN2	rs72930659			√		[60]
	rs35264875		√			[118]
	rs3829241		√			[118]
TYR	rs1042602		√			[40, 57, 68, 118]
	rs1393350		√			[57]
	rs13312741		√			[48]
	rs10831469		√			[68]
	rs1126809		√			[40, 118]
	rs1800422		√			[118]
TYRP1	rs2733832		√		√	[49, 118]
	rs2733831		√			[61]
	rs10809814		√			[49]
	rs2762464		√			[50]
	rs1408799		√		√	[40, 118]

The derived allele is associated with pigmentation in European populations

The derived allele is associated with pigmentation in East Asian populations