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. 2017 Jul 3;214(7):2153–2156. doi: 10.1084/jem.20160471

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© 2017 Bergman et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 2. — R22E treatment worsens insulitis in normoglycemic mice. Pancreas sections from nine control and six R22E-treated females normoglycemic at 30 wk of age (see Fig. 1 C) were scored blindly, all together at once, for insulitis severity. (A and B) Representative stainings used to identify insulin-producing islets (insulin/glucagon/Hoechst; A) and to score islets infiltration (hematoxylin and eosin; B). Bars, 100 µm. (C) Frequency of insulin-producing islets. (D) Frequency of infiltrated islets along a severity score (4 is most severe). ND, <50 islets detected.