Fig. 3. BAL T cell functionality in RMs & AGMs.
Characterization of (A) memory T cell lymphocyte subsets and their expression of (B) CD40L, (C) IL-2, (D) IFNγ, E) IL-5, and (F) IL-13 after SEB stimulation in RM shown in circles and AGM shown in squares. Closed symbols represent SIV-uninfected animals, while open symbols represent SIV-infected animals. (G) SPICE analysis illustrating number of functions in corresponding colored pie sections (legend on the left) and specific functionality as illustrated by the colored arcs (legend on the right). Multifunctional profile differences between cellular subsets (P-values) were assessed by the SPICE software permutation test. All horizontal bars in A–F reflect the median of that T cell subset. All P-values greater than 0.05 are represented as NS (not significant).