Table 5.

Diabetes-related loci discovered via genome-wide association studies as of 3/31/10; p<5.0×10⁻⁸

Reported gene	Associated SNPs	Region	Trait	Risk allele	Risk allele frequency†	Reference(s)
NOTCH2/ADAAM30	rs10923931	1p12	T2DM	T	0.093	[61]
PROX1	rs340874	1q32.3	FPG	C	0.562	[60]
THADA	rs7578597	2p21	T2DM	T	0.876	[61]
GCKR	rs780094	2p23.3	FPG/FI/HOMA-IR	C	0.606	[60]
G6PC2	rs560887	2q24.3	FPG	C	0.674	[216], [200]
			FPG/HOMA-B			[60]
LOC64673/IRS1	rs2943641	2q36.3	T2DM	C	0.633	[217]
ADAMTS9	rs4607103	3p14.1	T2DM	C	0.810	[61]
ADCY5	rs11708067	3q21.1	FPG/HOMA-B	A	0.774	[60]
SLC2A2	rs11920090	3q26.2	FPG	T	0.853	[60]
IGF2BP2	rs4402960	3q27.2	T2DM	T	0.296	[201], [126], [127]
	rs6769511		T2DM	C	JPT: 0.318	[194]*
WFS1/PPP2R2C	rs4689388	4p16.1	T2DM	T	0.668	[217]
CDKAL1	rs10946398	6p22.3	T2DM	C	0.336	[127]
	rs4712523		T2DM	G	0.336	[217]
					JPT: 0.511	[190]*
	rs4712524		T2DM	G	JPT: 0.511	[194]*
	rs6931514		T2DM	G	0.279	[61]
	rs7754840		T2DM	C	0.336	[126], [201]
	rs7756992		T2DM	G	0.279	[191]
GCK	rs4607517	7p13	FPG	A	0.195	[200]
			FPG/HOMA-B			[60]
JAZF1	rs864745	7p15.1	T2DM	T	0.487	[61]
DGKB/TMEM195	rs2191349	7p21.2	FPG/HOMA-B	T	0.467	[60]
ZMAT4	rs2722425	8p11.21	FPG	A**	0.093	[195]
SLC30A8	rs11558471	8q24.11	FPG	A	0.748	[60]
	rs13266634		T2DM	C	0.761	[201], [126], [127]
					JPT: 0.556	[190]*
CDKN2A/CDKN2B	rs10811661	9p21.3	T2DM	T	0.801	[201], [126], [127]
	rs2383208		T2DM	A	JPT: 0.568	[190]*
PTPRD	rs17584499	9p24.1	T2DM	T	CHB: 0.089	[196]*
GLIS3	rs7034200	9p24.2	FPG/HOMA-B	A	0.525	[60]
CDC123/CAMK1D	rs12779790	10p13	T2DM	G	0.229	[61]
HHEX	rs1111875	10q23.33	T2DM	C	0.584	[201], [126], [127]
					JPT: 0.409	[190]*
ADRA2A	rs10885122	10q25.2	FPG	G	0.900	[60]
TCF7L2	rs4506565	10q25.2	T2DM	T	0.296	[197]
			FPG			[60]
	rs7901695		T2DM	C	0.281	[127]
	rs7903146		T2DM	T	0.279	[191], [198], [192], [201], [126], [61], [217]
					JPT: 0.023	[190]*
CRY2	rs11605924	11p11.2	FPG	A	0.542	[60]
MADD	rs7944584	11p11.2	FPG	A	0.712	[60]
KCNJ11	rs5215	11p15.1	T2DM	C	0.398	[127]
	rs5219		T2DM	T	0.500	[126], [201]
KCNQ1	rs2237895	11p15.4	T2DM	C	CHB: NR	[196]*
	rs2237892		T2DM	C	JPT: 0.611	[193]*, [190]*
	rs2283228		T2DM	A	JPT: 0.593	[194]*
FADS1	rs174550	11q12.2	FPG/HOMA-B	T	0.633	[60]
MTNR1B	rs10830963	11q14.3	FPG/HOMA-B	G	0.300	[60], [200]
	rs1387153		FPG	T	0.272	[188]
	rs2166706		FPG	G	0.389	[189]*
					CHB: 0.489
TSPAN8/LGR5	rs7961581	12q21.1	T2DM	C	0.252	[61]
IGF1	rs35767	12q23.2	FI/HOMA-IR	G	0.885	[60]
C2CD4B	rs11071657	15q22.2	FPG	A	0.592	[60]
FTO	rs8050136	16q12.2	T2DM	A	0.460	[126], [127]
SRR	rs391300	17p13.3	T2DM	G	CHB: 0.740	[196]*

^†HapMap release 27, CEU population unless otherwise noted;

^*Includes individuals of non-European descent;

^**minor allele and MAF reported, risk allele was not reported in paper; T2DM, type 2 diabetes mellitus; FPG, fasting plasma glucose; FI, fasting insulin; HOMA-IR, homeostatic model assessment of insulin resistance; HOMA-B, homeostatic model assessment of beta-cell function; NR, not reported