Table 2.

Presence of TLR pathway-signaling homologs in deuterostomes

	TIR domain-containing adaptors					Signaling mediators
Taxon	MYD88	TIRAP	TCAM1	TCAM2	SARM1	IRAK1/4	TRAF6	TAB1	TAB2	M3K7
Hemichordata	+	+		+	+	+	+	+	+	+
Echinodermata	+				+	+	+*	+	+	+
Cephalochordata	+	+		+	+	+	+	+	+	+
Tunicata	+				+	+	+*	+	+	+
Vertebrates	+	+	+	+	+	+	+	+	+	+

See Fig. S2 for species-specific homolog numbers.

^*Identified only in targeted molecular studies (16, 61).