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Aquaretic effect of mambaquaretin-1. (A and B) Increase in urinary volume (A) and decrease in urine osmolality (B) after daily administration of mambaquaretin-1 at three doses to pcy mice and to C57BL/6 mice (violet curve, one dose) for 6 d. (C–F) Monitoring of (C) diuresis, (D) urine osmolality, (E) excretion of proteins, and (F) electrolytes during the 99-d treatment with 0.1 mol/kg BW of mambaquaretin-1. Data are presented as mean SD, n = 6–7.
