Table 1.

Main results of statistical significance tests based on A2DS

Test index	Test set (T)	DS	A2DS (×106)	Estimated P value
1	SSC affected n= 2,591	SSC DS n = 2,113	5.99	1 × 10−5*
2	SSC affected in quads n = 2,113	SSC DS n = 2,113	5.02	0.00306*
3	SSC affected in trios n = 4,78	SSC DS n = 2,113	10.29	0.01104*
4	SSC unaffected in quads n = 2,113	SSC DS n = 2,113	−0.55	0.3753
5	SSC fathers n = 2,591	SSC DS n = 2,113	0.24	0.4405
6	SSC mothers n = 2,591	SSC DS n = 2,133	−0.20	0.5475
7	SSC white affected n = 1,816	SSC white DS n = 1,489	5.21	0.0078
8	SSC affected n = 2,591	SSC male–male DS n = 924	6.53	0.0003
9	SSC male affected n = 2,246	SSC male–male DS n = 924	5.27	0.0078
10	AGRE affected n = 1,374 (one affected selected from each family based on IQ)	SSC DS n = 2,113	11.40	0.01478*
11	AGRE unaffected n = 615 (one unaffected sibling selected from each family)	SSC DS n = 2,113	−0.53	0.5695
12	AGRE mothers n = 1,232	SSC DS n = 2,113	2.28	0.2241
13	AGRE fathers n = 1,142	SSC DS n = 2,113	6.34	0.0206
14	AGRE + SSC affected n = 2,591 + 1,374	SSC DS n = 2,113	7.87	4 × 10−5*

Columns 2 and 3 list the test sets and corresponding discordant sibships (DS). Column 4 shows the A2DS value ×10⁶, and column 5 shows the estimated P values from 10,000 random permutations, except where indicated.

^*Estimated P values from 100,000 random permutations.