. 2017 May 30;114(27):7160–7165. doi: 10.1073/pnas.1705154114

Table 1.

Radioligand-binding analysis

Ligand	K_i for TMEM97 in Sf9 cells, nM	σ₂ K_i, nM
DTG	19.6 ± 3.0	21.2^*
Haloperidol	54.1 ± 6.7	48.7^*
PB-28	2.0 ± 0.3	1.8^†
(+)-pentazocine	2,467 ± 436	1,402^* – 3,890^†
(+)-SKF 10,047	>10,000	No inhibition^*
SAS-1121	25.2 ± 3.8	23.8^‡
Elacridar	6.5 ± 1.1	4.7 ± 0.7
Ro 48-8071	971 ± 228	817 ± 226

The inhibition constant (K_i) for various ligands binding to recombinant TMEM97 and to the σ₂ receptor natively expressed in cell membranes. Affinities were measured as described in Methods and are reported from literature where indicated.

Data from Hellewell and Bowen, 1990 (3).

^{^†}

Data from Colabufo et al., 2004 (49).

^{^‡}

Data from Sahn et al., 2017 (20).