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Proposed model by which PS1 increases autophagic flux and decreases Aβ levels. PS1, upon phosphorylation on Ser367 by CK1γ, interacts with Annexin A2 (AnxA2). In turn, Annexin A2 interacts with Vamp8, which facilitates the binding of Vamp8 to Stx17. This interaction induces the lysosome-autophagosome fusion, triggering the degradation of βCTF, leading to a decrease in Aβ levels. P, phosphorylation.
