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Comparison of predicted topology and crystal structure of the sigma1 and sigma2 receptors. (A) Topology model of the sigma1 receptor. Reproduced from Laurini et al. (26). (B) Space-fill model of the sigma1 crystal structure with the bound ligand in yellow. Reproduced from Schmidt et al. (5). (C) Topology model of TMEM97/sigma2 receptor. Reproduced from Alon et al. (6). (D) Question regarding crystal structure of TMEM97/sigma2 receptor.
