Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic representation of insulin/Akt/EAAT signaling pathway. a Insulin binding to IR-α induces dimerization and autophosphorylation of IR-β, which subsequently triggers Akt phosphorylation. mTOR is an important downstream target of Akt, and Akt activation can result in increased phosphorylation of mTOR, which then induces EAAT protein synthesis. b Aβ oligomers can destroy the IRs, disrupting expression of the downstream substrates and disturbing glutamate metabolism
