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. Author manuscript; available in PMC: 2018 Jun 15.
Published in final edited form as: Bioorg Med Chem Lett. 2017 Apr 21;27(12):2752–2756. doi: 10.1016/j.bmcl.2017.04.065

Table 1. Structures and IC50 Values of Ipomoeassin F and Its Analogues.

graphic file with name nihms874074t1.jpg Compounds structure IC50(nM)
R1 R2 MDA-MB-231 MCF7 HeLa U937 Jurkat
ipomoeassin F Ac H 6.5 43.7 16.4 5.4 6.1
1 H H 131 86.7 133 72.5 139
2 Ac Ac 16.5 216 138 79.8 82.6