TABLE 1.
Patient Characteristics
| Total | N (%) |
|---|---|
|
| |
| Age at enrollment, mean (SD), y | 11.9 (4.6) |
|
| |
| Age at first attack, mean (SD), y | 8.7 (4.9) |
|
| |
| Sex, female | 172 (57) |
|
| |
| Ethnicity, Hispanic | 63/276 (23) |
|
| |
| Race, n = 265 | |
| White | 214 (81) |
| Multi-racial | 20 (8) |
| Black | 10 (4) |
| Asian | 14 (5) |
| Other | 7 (3) |
|
| |
| ARP | 155 (52) |
| CP | 146 (48) |
| Exocrine insufficiency | 46/259 (18) |
| Endocrine insufficiency | 13/278 (5) |
|
| |
| Risk factors | |
| Toxic-metabolic | 23/195 (12) |
| •Medications | 7/287 (2) |
| •Ethanol exposure | 4/287 (1) |
| •Active smoker | 24/269 (9) |
| •Passive smoke exposure | 30/220 (14) |
| Autoimmune | 97/296 (33) |
| Obstructive factors | |
| Genetic risk factors | |
| •PRSS1 | 65/196 (33) |
| •SPINK1 | 35/177 (20) |
| •CFTR | 54/193 (28) |
| •CTRC | 9/121 (7) |
|
| |
| Therapies Attempted | 194/294 (66) |
| •Medical therapies | 145/289 (50) |
| •Therapeutic ERCP utilization | 117/301 (39) |
| •Surgery (non-TPIAT) | 61/292 (21) |
| •TPIAT | 29/291 (10) |
SD: standard deviation, ARP: acute recurrent pancreatitis, CP: chronic pancreatitis, PRSS1: protease, serine 1, SPINK1: serine peptidase inhibitor, Kazal type 1, CFTR: cystic fibrosis transmembrane conductance regulator, CTRC: chymotrypsin C, ERCP: endoscopic retrograde cholangiopancreatography, TPIAT: total pancreatectomy and islet autotransplantation.