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Viability of BxPC-3 cells cultured as monolayers (A) and three-dimensional spheroids (B) after treatment with DSPC LNs encapsulating gemcitabine (20 µM), free gemcitabine (20 µM), gemcitabine encapsulated hypoxia-responsive LNs devoid of surface iRGD peptide, and the hypoxia-sensitive LNs with the iRGD under normoxic (red bars) and hypoxic conditions (green bars).
