Table 4.

Univariable and Multivariable Analyses of Time to Recurrence, time to progression, duration of Bladder Cancer Specific and overall survival

	Univariable		Multivariable
	HR (95% CI)	p value	HR (95%CI)	p value
Recurrence*
Muscle (no/yes)	0.95 (0.92–0.98)	0.001	0.95 (0.91–0.99)	0.04
reTUR (no/yes), No muscle	0.97 (0.74–1.27)	0.80	0.67 (0.42–1.04)	0.08
reTUR (no/yes), Muscle	1.30 (1.14–1.49)	< 0.001	1.38 (1.17–1.64)	< 0.001
reTUR (no/yes), All patients	1.28 (1.14–1.43)	< 0.001	1.27 (1.09–1.49)	0.002
Progression**
Muscle (no/yes)	0.99 (0.94–1.03)	0.56	1.00 (0.94–1.06)	0.97
reTUR (no/yes), No muscle	0.59 (0.36–0.96)	0.03	0.46 (0.20–1.03)	0.06
reTUR (no/yes), Muscle	1.01 (0.81–1.26)	0.95	1.20 (0.93–1.55)	0.17
reTUR (no/yes), All patients	0.92 (0.76–1.11)	0.39	1.10 (0.86–1.39)	0.45
Disease Specific Survival***
Muscle (no/yes)	1.03 (.97–1.09)	0.28	1.08 (1.01–1.15)	0.03
reTUR (no/yes), No muscle	0.56 (0.29–1.11)	0.10	0.31 (0.09–1.08)	0.07
reTUR (no/yes), Muscle	1.29 (0.93–1.78)	0.13	1.60 (1.11–2.31)	0.01
reTUR (no/yes), All patients	1.09 (0.82–1.43)	0.56	1.32 (0.95–1.84)	0.10
Overall Survival***
Muscle (no/yes)	0.99 (0.95–1.03)	0.62	1.02 (0.98–1.07)	0.98
reTUR (no/yes), No muscle	0.66 (0.44–0.99)	0.05	0.48 (0.23–1.00)	0.05
reTUR (no/yes), Muscle	0.99 (0.81–1.22)	0.95	1.23 (0.97–1.56)	0.09
reTUR (no/yes), All patients	0.92 (0.78–1.10)	0.37	1.09 (0.88–1.35)	0.45

Note:

• HR < 1: better outcome when muscle is present, better outcome when a reTUR is done
• HR > 1: worse outcome when muscle is present, worse outcome when a reTUR is done

^*Recurrence adjusted for number of tumors, tumor size and maintenance BCG

^**Progression adjusted for age, tumor size, CIS and maintenance BCG

^***Survival adjusted for age, tumor size and maintenance BCG