Table 4.
PRDM9 ZF alleles detected among MI zero cases heterozygous for the PRDM9 major A allele.
| Allele | Controls | Cases | Predicted Binding Sequence | Number of Predicted Binding Sequences on 21q |
|---|---|---|---|---|
| L20* | 1 | 1 | CCGCCNCGNCCNC | * |
| L24,L9**** | 8 | CCGCCGTGNCCNC | 7 | |
| N ** | 6 | CCGCCGTNNCCNC | 36 | |
| O1 | 2 | CCGCCGGGNCCNC | 16 | |
| O2*** | 1 | CGGTTAGCGTGNC | 0 | |
| O3 | 1 | CGGCCGTGNCCNC | 7 | |
| O4 | 1 | CGGCCGGGNCCNC | 10 | |
| B | 5 | CCGCCGTNNCCNC | 36 | |
| C*** | 1 | CCNCGGTTAGCGTGN | 0 | |
| L33 | 1 | CCGCCGTGNCCNC | 6 | |
| L34 | 1 | CCGCCGTGNCCNC | 6 | |
| N2**** | 6 | CCGCCGTGNCCNC | 7 |
The predicted binding sequence for PRDM9 major A-allele is CCGCCGTNNCCNC. The values indicted under the columns labelled cases and controls represent the number of heterozygous carriers of the major A-allele. The minor allele for these samples and its predicted binding-sequence is indicated.
The L20 PRDM9 ZF allele had >100 predicted binding sequences on 21q.
Samples heterozygous for the major A-allele that contain a minor allele that has a predicted binding sequence identical to the PRDM9 major-A-Allele. These alleles have not been previously reported by previous studies.
The O2 and C alleles had no predicted binding sequences on 21q.
Samples heterozygous for the major A-allele that contain a minor allele that has a predicted binding sequence identical to the PRDM9 L24 allele.