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. Author manuscript; available in PMC: 2018 Feb 28.
Published in final edited form as: Biochemistry. 2017 Feb 16;56(8):1140–1150. doi: 10.1021/acs.biochem.6b01030

Table 3. k2/Ks second order rate constants for acylation.

The values represent the mean ± standard deviation for 3 independent determinations.

PBP2 Variant k2/KS (M−1s−1)
Cefixime Ceftriaxone Penicillin G
PBP2 1480000 ± 22000   1710000 ± 90000 75700 ± 2300
PBP235/02 7170 ± 280 11300 ± 440 510 ± 90
PBP235/02-A501T 5550 ± 160 30400 ± 300 1860 ± 130
PBP235/02-A501V 3150 ± 120 20000 ± 390 1370 ± 140
PBP235/02-A501R 820 ± 40 6460 ± 70   960 ± 100
PBP235/02-A501P 40 ± 1   250 ± 20 810 ± 40