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. 2017 Jun 21;13:1744806917718753. doi: 10.1177/1744806917718753

Figure 4.

Figure 4.

NF-κB activation mediated PI-induced upregulation of CXCL12 in spinal cord. (a) Western blotting data showing an increased level of phosphorylated NF-κB p65 (p-p65), but not total p65, in spinal cord following PI. *P < 0.05 versus sham group, one-way ANOVA. (b) Prior i.t. administration of PDTC inhibited activation of NF-κB and reduced CXCL12 expression in spinal cord following PI. *P < 0.05 versus sham + vehicle (Veh) group; #P < 0.05 versus PI + Veh group, one-way ANOVA. (c, d) Repetitive given rats of PDTC intrathecally prevented the reduction of PWT (c) and PWL (d) after PI. *P < 0.05; **P < 0.01 versus PI + saline group, Student's t-test. #P < 0.05; ##P < 0.01; ###P < 0.001 versus baseline value, two-way ANOVA.