Fig. 3.

Systemic treatment with deferasirox reduces peripheral iron content. A) Urinary iron content was doubled at 1 dpi in control animals compared to pre-injury levels. Urine from rats receiving deferasirox had significantly more iron compared to pre-injury values and to 1 dpi vehicle-treated values. B) One week after daily deferasirox treatments (160 mg/kg/day), liver iron content was significantly decreased. C) Representative images of liver sections stained for iron in black showing a significant reduction in hepatic iron following deferasirox treatment. A: ***p < 0.001 deferasirox 1 dpi vs. vehicle 1 dpi; ^^^p < 0.01 deferasirox 1 dpi vs. naïve baseline. B: *p < 0.05 deferasirox vs. control and vehicle.