Table 2.
CLD-associated proteins common among all genotypes.
| Protein | Gene | UniProt ID | Function |
|---|---|---|---|
| Alpha-enolase | Eno1 | P17182 | Carbohydrate Metabolism |
| ATP synthase subunit alpha, mitochondrial | Atp5a1 | Q03265 | Carbohydrate Metabolism |
| ATP synthase subunit beta, mitochondrial | Atp5b | P56480 | Carbohydrate Metabolism |
| Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing) | Dak | Q8VC30 | Carbohydrate Metabolism |
| Fructose-bisphosphate aldolase B | Aldob | Q91Y97 | Carbohydrate Metabolism |
| Glyceraldehyde-3-phosphate dehydrogenase | Gm3839 | P16858 | Carbohydrate Metabolism |
| Malate dehydrogenase, cytoplasmic | Mdh1 | P14152 | Carbohydrate Metabolism |
| Malate dehydrogenase, mitochondrial | Mdh2 | P08249 | Carbohydrate Metabolism |
| Pyrethroid hydrolase Ces2e | Ces2e | Q8BK48 | Carbohydrate Metabolism |
| Pyruvate kinase PKM | Pkm | P52480 | Carbohydrate Metabolism |
| 78 kDa glucose-regulated protein | Hspa5 | P20029 | Cell Stress Response |
| Apoptosis-associated speck-like protein containing a CARD | Pycard | Q9EPB4 | Cell Stress Response |
| Bifunctional 3-phosphoadenosine 5- phosphosulfate synthase 2 | Papss2 | O88428 | Cell Stress Response |
| Bifunctional epoxide hydrolase 2 | Ephx2 | P34914 | Cell Stress Response |
| Glutathione S-transferase Mu 3 | Gstm3 | P19639 | Cell Stress Response |
| Glutathione S-transferase P 1 | Gstp1 | P19157 | Cell Stress Response |
| Hemoglobin subunit beta-1 | Hbbt1 | A8DUK4 | Cell Stress Response |
| Protein disulfide-isomerase | P4hb | P09103 | Cell Stress Response |
| Superoxide dismutase [Cu-Zn] | Sod1 | P08228 | Cell Stress Response |
| Tpm1 | G5E8R0 | Cell Stress Response | |
| Actin, cytoplasmic 2 | Actg1 | P63260 | Cytoskeleton Organization |
| Annexin | Anxa2 | B0V2N7 | Cytoskeleton Organization |
| Tubulin alpha-1C chain | Tuba1c | P68373 | Cytoskeleton Organization |
| Tubulin beta-4B chain | Tubb4b | P68372 | Cytoskeleton Organization |
| Villin-1 | Vil1 | Q62468 | Cytoskeleton Organization |
| Acylcarnitine hydrolase | Ces2c | Q91WG0 | Lipid Metabolism |
| Apolipoprotein A-I | Apoa1 | Q00623 | Lipid Metabolism |
| Estradiol 17-beta-dehydrogenase 11 | Hsd17b11 | Q9EQ06 | Lipid Metabolism |
| Fatty acid-binding protein, intestinal | Fabp2 | P55050 | Lipid Metabolism |
| Fatty acid-binding protein, liver | Fabp1 | P12710 | Lipid Metabolism |
| Microsomal triglyceride transfer protein large subunit | Mttp | O08601 | Lipid Metabolism |
| NADH-cytochrome b5 reductase 3 | Cyb5r3 | Q9DCN2 | Lipid Metabolism |
| Perilipin-3 | Plin3 | Q9DBG5 | Lipid Metabolism |
| Creatine kinase U-type, mitochondrial | Ckmt1 | P30275 | Mitochondria/Redox |
| Cytochrome b5 | Cyb5a | G5E850 | Mitochondria/Redox |
| Dehydrogenase/reductase SDR family member 1 | Dhrs1 | Q99L04 | Mitochondria/Redox |
| Histone H2A type 1-H | Hist1h2ah | Q8CGP6 | Nucleosome Assembly |
| Histone H2B type 1-P | Hist1h2bp | Q8CGP2 | Nucleosome Assembly |
| Histone H4 | Hist1h4a | P62806 | Nucleosome Assembly |
| Heat shock protein HSP 90-beta | Hsp90ab1 | P11499 | Protein Folding |
| 14-3-3 protein zeta/delta | Ywhaz | P63101 | Protein Localization/Transport |
| Alpha-actinin-4 | Actn4 | P57780 | Protein Localization/Transport |
| Annexin A4 | Anxa4 | P97429 | Protein Localization/Transport |
| Clathrin heavy chain | Cltc | Q5SXR6 | Protein Localization/Transport |
| 40S ribosomal protein SA | Rpsa | P14206 | Translation |
| Elongation factor 1-alpha 1 | Eef1a1 | P10126 | Translation |
| Elongation factor 1-delta | Eef1d | D3Z7N2 | Translation |
| Heterogeneous nuclear ribonucleoproteins A2/B1 | Hnrnpa2b1 O88569 | Translation | |
| Calmodulin | Calm1 | P62204 | Other (Calcium Mediated Signaling) |
| Galectin-2 | Lgals2 | Q9CQW5 | Other (Carbohydrate Binding, Unknown Function) |
| Galectin-4 | Lgals4 | Q8K419 | Other (Carbohydrate Binding, Unknown Function) |
| Heat shock cognate 71 kDa protein | Hspa8 | P63017 | Other (Protein Metabolism) |
| Sodium/potassium-transporting ATPase subunit alpha-1 | Atp1a1 | Q8VDN2 | Other (Ion Transport) |