Table 3.
CLD-associated proteins unique to one, two, or three genotypes.
| Protein | Gene | UniProt ID | Function |
|---|---|---|---|
| Dgat1Int | |||
| Cytochrome b-c1 complex subunit 1, mitochondrial | Uqcrc1 | Q9CZ13 | Carbohydrate Metabolism, Mitochondria/Redox |
| Guanine deaminase | Gda | Q9R111 | Carbohydrate Metabolism |
| Diacylglycerol O-acyltransferase 1 | Dgat1 | Q9Z2A7 | Lipid Metabolism |
| WT | |||
| Carbonyl reductase [NADPH] 1 | Cbr1 | P48758 | Carbohydrate Metabolism |
| Dgat2Int | |||
| Aldehyde dehydrogenase X, mitochondrial | Aldh1b1 | Q9CZS1 | Carbohydrate Metabolism |
| Cytochrome c oxidase subunit 2 | Mtco2 | P00405 | Carbohydrate Metabolism |
| Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit | Ddost | O54734 | Carbohydrate Metabolism |
| Ornithine aminotransferase, mitochondrial | Oat | P29758 | Carbohydrate Metabolism |
| Ces2g | E9PV38 | Hydrolase | |
| Peroxisomal multifunctional enzyme type 2 | Hsd17b4 | P51660 | Lipid Metabolism |
| V-type proton ATPase catalytic subunit A | Atp6v1a | P50516 | Nucleotide Biosynthesis |
| Zymogen granule membrane protein 16 | Zg16 | Q8K0C5 | Protein Localization/Transport |
| T-complex protein 1 subunit delta | Cct4 | G5E839 | Protein Metabolism |
| Dgat1−/− | |||
| 4-trimethylaminobutyraldehyde dehydrogenase | Aldh9a1 | Q9JLJ2 | Carbohydrate Metabolism |
| 6-phosphogluconate dehydrogenase, decarboxylating | Pgd | Q9DCD0 | Carbohydrate Metabolism |
| Aldehyde dehydrogenase family 16 member A1 | Aldh16a1 | D3Z0B9 | Carbohydrate Metabolism |
| Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 | Gfpt1 | P47856 | Carbohydrate Metabolism |
| Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic | Gpd1 | E0CXN5 | Carbohydrate Metabolism |
| Isocitrate dehydrogenase [NADP] cytoplasmic | Idh1 | O88844 | Carbohydrate Metabolism, Cell Stress Response |
| Cell death activator CIDE-B | Cideb | O70303 | Cell Stress Response |
| Nucleophosmin | Npm1 | Q5SQB0 | Cell Stress Response, Cytoskeletal Organization |
| Peroxiredoxin-1 | Prdx1 | B1AXW5 | Cell Stress Response |
| Peroxiredoxin-2 | Prdx2 | Q61171 | Cell Stress Response |
| Peroxiredoxin-5, mitochondrial | Prdx5 | G3UZJ4 | Cell Stress Response |
| Adenylyl cyclase-associated protein 1 | Cap1 | P40124 | Cytoskeleton Organization |
| Destrin | Dstn | Q9R0P5 | Cytoskeletal Organization |
| Cytochrome P450 2D26 | Cyp2d26 | Q8CIM7 | Mitochondria/Redox |
| Bifunctional purine biosynthesis protein PURH | Atic | Q9CWJ9 | Nucleotide Biosynthesis, Mitochondria/Redox |
| Eukaryotic translation initiation factor 5A-1 | Eif5a | J3QPS8 | Protein Localization/Transport |
| Poly(rC)-binding protein 1 | Pcbp1 | P60335 | RNA Processing |
| Small nuclear ribonucleoprotein Sm D3 | Snrpd3 | P62320 | RNA Processing |
| Dgat1Int, WT | |||
| 40S ribosomal protein S8 | Rps8 | P62242 | Translation |
| Dgat1Int, Dgat2Int | |||
| Beta-1,4 N-acetylgalactosaminyltransferase 2 | B4galnt2 | Q09199 | Carbohydrate Metabolism |
| Catalase | Cat | P24270 | Cell Stress Response |
| Transmembrane 9 superfamily member 2 | Tm9sf2 | P58021 | Unknown Function |
| WT, Dgat2Int | |||
| Heat shock protein HSP 90-alpha | Hsp90aa1 | P07901 | Protein Localization/Transport |
| WT, Dgat1−/− | |||
| L-lactate dehydrogenase A chain | Ldha | P06151 | Carbohydrate Metabolism |
| NSFL1 cofactor p47 | Nsfl1c | Q9CZ44 | Cell Stress Response |
| Cofilin-1 | Cfl1 | F8WGL3 | Cytoskeleton Organization |
| Creatine kinase B-type | Ckb | Q04447 | Kinase, Transferase |
| Glutathione S-transferase | Gsta2 | D3Z6A6 | Transferase |
| 40S ribosomal protein S14 | Rps14 | P62264 | Translation |
| 40S ribosomal protein S3 | Rps3 | D3YV43 | Translation |
| Fcgbp | E9Q9C6 | Unknown Function | |
| Dgat2Int, Dgat1−/− | |||
| 14-3-3 protein epsilon | Ywhae | P62259 | Protein Localization/ Transport |
| 40S ribosomal protein S15 | Rps15 | P62843 | Translation |
| 40S ribosomal protein S18 | Rps18 | F6YVP7 | Translation |
| Dgat1Int, WT, Dgat2Int | |||
| Nucleobindin-1 | Nucb1 | H3BK79 | Calcium Ion Binding, Unknown Function |
| Apolipoprotein A-IV | Apoa4 | P06728 | Lipid Metabolism |
| Retinal dehydrogenase 1;Aldehyde dehydrogenase, cytosolic 1 | Aldh1a1 | O35945 | Lipid Metabolism |
| Dgat1Int, Dgat2Int, Dgat1−/− | |||
| Protein disulfide-isomerase A3 | Pdia3 | P27773 | Cell Stress Response |
| Protein disulfide-isomerase A6 | Pdia6 | Q3TML0 | Cell Stress Response |
| Myosin-14 | Myh14 | K3W4R2 | Cytoskeletal Organization |
| Myosin-9 | Myh9 | Q8VDD5 | Cytoskeletal Organization |
| Cytochrome P450 2B10 | Cyp2b10 | Q9WUD0 | Lipid Metabolism |
| Long-chain-fatty-acid--CoA ligase 5 | Acsl5 | Q8JZR0 | Lipid Metabolism |
| Aconitate hydratase, mitochondrial | Aco2 | Q99KI0 | Mitochondria/Redox |
| Cytochrome b5 type B | Cyb5b | Q9CQX2 | Mitochondria/Redox |
| Synaptic vesicle membrane protein VAT-1 homolog | Vat1 | Q62465 | Mitochondria/Redox |
| Ras-related protein Rab-2A | Rab2a | P53994 | Protein Localization/Transport |
| Peptidyl-prolyl cis-trans isomerase A | Ppia | P17742 | Protein Metabolism |
| 40S ribosomal protein S3a | Rps3a | P97351 | Translation |
| 60S ribosomal protein L13 | Rpl13 | P47963 | Translation |
| 60S ribosomal protein L7 | Rpl7 | P14148 | Translation |
| WT, Dgat2Int, Dgat1−/− | |||
| Fructose-1,6-bisphosphatase isozyme 2 | Fbp2 | P70695 | Carbohydrate Metabolism |
| Transketolase | Tkt | P40142 | Carbohydrate Metabolism |
| Heterogeneous nuclear ribonucleoprotein K | Hnrnpk | B2M1R6 | Cell Stress Response |
| Purine nucleoside phosphorylase | Pnp | Q543K9 | Cell Stress Response |
| Ubiquitin-like modifier-activating enzyme 1 | Uba1 | Q02053 | Cell Stress Response |
| Plastin-1 | Pls1 | Q3V0K9 | Cytoskeletal Organization |
| Leukotriene A-4 hydrolase | Lta4h | P24527 | Lipid Metabolism |
| Guanine nucleotide-binding protein subunit beta- 2-like 1 | Gnb2l1 | P68040 | Protein Localization/Transport |
| Transitional endoplasmic reticulum ATPase | Vcp | Q01853 | Protein Localization/Transport |
| Leukocyte elastase inhibitor A | Serpinb1a | Q9D154 | Protein Metabolism |
| Elongation factor 2 | Eef2 | P58252 | Translation |