Table 2.
Logistic regression analyses of associations between TCF21 rs2327429 T>C, rs2327433 A>G, rs2327433 A>G, rs12190287 C>G, and rs4896011 T>A polymorphisms and risk of osteosarcoma.
| TCF21 Genotype |
Cases (n=225) | Controls (n=250) | Crude OR (95%Cl) | P | Adjusted OR (95%Cl) | P | ||
|---|---|---|---|---|---|---|---|---|
| n | % | n | % | |||||
| rs2327429 T>C | ||||||||
| TT | 10 | 4.44 | 9 | 3.60 | 1.00 | 1.00 | ||
| TC | 41 | 18.22 | 49 | 19.60 | 0.93 (0.51–1.23) | 0.880 | 0.95 (0.52–1.24) | 0.901 |
| CC | 174 | 77.33 | 192 | 76.80 | 1.20 (0.80–1.76) | 0.765 | 1.19 (0.80–1.76) | 0.780 |
| TC+CC | 215 | 95.56 | 241 | 96.40 | 1.17 (0.55–1.64) | 0.755 | 1.18 (0.55–1.72) | 0.759 |
| TT+TC | 51 | 22.67 | 60 | 23.2 | 1.00 | 1.00 | ||
| CC | 174 | 77.33 | 226 | 76.8 | 1.01 (0.57–1.25) | 0.498 | 0.99 (0.55–1.20) | 0.169 |
| rs2327433 A>G | ||||||||
| AA | 20 | 8.89 | 27 | 10.80 | 1.00 | 1.00 | ||
| AG | 101 | 44.89 | 118 | 47.20 | 0.95 (0.51–1.63) | 0.682 | 0.98 (0.54–1.67) | 0.805 |
| GG | 104 | 46.22 | 105 | 42.00 | 1.17 (0.76–2.21) | 0.614 | 1.18 (0.19–2.31) | 0.542 |
| AG+GG | 205 | 91.11 | 249 | 89.20 | 1.09 (0.64–1.80) | 0.719 | 1.08 (0.64–1.79) | 0.798 |
| AA+AG | 121 | 53.78 | 165 | 58.00 | 1.00 | 1.00 | ||
| GG | 104 | 46.22 | 121 | 42.00 | 1.29 (0.89–1.70) | 0.266 | 1.20 (0.87–1.73) | 0.268 |
| rs2327433 A>G | ||||||||
| AA | 101 | 44.89 | 110 | 44.00 | 1.00 | 1.00 | ||
| AG | 82 | 36.44 | 96 | 38.40 | 0.95 (0.78–1.20) | 0.520 | 0.89 (0.68–1.21) | 0.526 |
| GG | 42 | 18.67 | 44 | 17.60 | 1.05 (0.72–1.43) | 0.571 | 1.15 (0.73–1.54) | 0.627 |
| AG+GG | 124 | 55.11 | 168 | 56.00 | 0.92 (0.66–1.26) | 0.893 | 0.93 (0.67–1.29) | 0.880 |
| AA+AG | 183 | 81.33 | 240 | 82.40 | 1.00 | 1.00 | ||
| GG | 42 | 18.67 | 46 | 17.60 | 1.05 (0.71–1.63) | 0.309 | 1.09 (0.81–1.74) | 0.310 |
| rs12190287 C>G | ||||||||
| CC | 89 | 39.56 | 139 | 55.70 | 1.00 | 1.00 | ||
| CG | 113 | 50.22 | 84 | 33.60 | 1.75 (1.21–2.41) | 0.002* | 1.77 (1.20–2.39) | 0.002* |
| GG | 23 | 10.22 | 27 | 10.80 | 1.32 (1.05–1.99) | 0.048* | 1.35 (1.07–2.01) | 0.043* |
| CG+GG | 136 | 60.44 | 111 | 44.40 | 1.70 (1.29–2.31) | 0.003* | 1.72 (1.30–2.32) | 0.003* |
| CC+CG | 202 | 89.78 | 223 | 89.30 | 1.00 | 1.00 | ||
| GG | 23 | 10.22 | 27 | 10.80 | 1.17 (0.63–2.04) | 0.205 | 1.17 (0.62–2.05) | 0.205 |
| rs4896011 T>A | ||||||||
| TT | 28 | 12.44 | 30 | 12.00 | 1.00 | 1.00 | ||
| TA | 83 | 36.89 | 101 | 40.40 | 0.71 (0.31–1.23) | 0.369 | 0.70 (0.38–1.20) | 0.393 |
| AA | 114 | 50.67 | 119 | 47.60 | 0.86 (0.55–1.57) | 0.491 | 0.92 (0.55–1.55) | 0.503 |
| TA+AA | 197 | 86.38 | 230 | 88.00 | 0.73 (0.50–1.35) | 0.756 | 0.72 (0.50–1.31) | 0.733 |
| TT+TA | 111 | 47.31 | 131 | 52.40 | 1.00 | 1.00 | ||
| AA | 114 | 50.67 | 119 | 47.60 | 1.11 (0.87–1.49) | 0.205 | 1.20 (0.86–1.68) | 0.276 |
*
Statistically significant (P<0.05).