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. 2017 Jul 10;12(7):e0180163. doi: 10.1371/journal.pone.0180163

Fig 1. Topology of eukaryotic ClC proteins.

Fig 1

A schematic diagram of the ClC protein containing transmembrane catalytic domain and cytoplasmic regulatory domain. The topology of the transmembrane domain is based on the ClC-ec1 protein. The 18 α helices are labeled from A-R. The two halves of the subunits are shown in two different shades of gray. The regions and sequences that contribute to the chloride selectivity filter are marked with black arrows and the respective conserved sequences are indicated (amino acids are abbreviated with their one-letter codes, / (forward slash): or, X: any amino acid). The two cytoplasmic cystathionine beta synthase (CBS) subdomains are shown in rounded rectangles (CBS1 and CBS2).