Table 2. Association of cleaved caspase-3 (CC-3), caspase-3 (C-3), caspase-8 (C-8) and caspase-9 (C-9) expression levels with demographical characteristics and pathological outcomes of OTSCC patients (base of tongue was excluded).
| Variable | No. (%) | CC-3 | C-3 | C-8 | C-9 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean±SD | Median | p value | Mean±SD | Median | p value | Mean±SD | Median | p value | Mean±SD | Median | p value | ||
| Sex | |||||||||||||
| Female | 29 (11.8) | 0.86±1.09 | 0.00 | 0.115* | 4.93±1.33 | 5.00 | 0.369* | 6.76±0.51 | 7.00 | 0.246† | 5.93±0.84 | 6.00 | 0.019† |
| Male | 217 (88.2) | 1.23±1.17 | 1.00 | 4.67±1.47 | 5.00 | 6.60±0.65 | 7.00 | 5.37±1.19 | 5.00 | ||||
| Age, y | |||||||||||||
| ≦40 | 47 (19.1) | 1.19±1.14 | 1.00 | 0.965‡ | 4.28±1.42ab | 4.00 | 0.023§ | 6.68±0.59c | 7.00 | 0.003§ | 5.62±1.13 | 6.00 | 0.578‡ |
| 41–50 | 79 (32.1) | 1.19±1.18 | 1.00 | 4.57±1.64 | 5.00 | 6.80±0.46de | 7.00 | 5.47±1.16 | 6.00 | ||||
| 51–60 | 67 (27.2) | 1.22±1.08 | 1.00 | 5.01±1.29a | 5.00 | 6.57±0.68d | 7.00 | 5.31±1.17 | 5.00 | ||||
| >60 | 53 (21.5) | 1.11±1.30 | 1.00 | 4.89±1.28b | 5.00 | 6.38±0.77ce | 7.00 | 5.40±1.21 | 5.00 | ||||
| Cell differentiation | |||||||||||||
| Well | 26 (10.6) | 1.08±1.09 | 1.00 | 0.024§ | 5.04±1.22 | 5.00 | 0.281‡ | 6.54±0.71 | 7.00 | 0.642§ | 5.31±1.19g | 5.50 | 0.007‡ |
| Moderate | 203 (82.5) | 1.26±1.19f | 1.00 | 4.64±1.47 | 5.00 | 6.62±0.64 | 7.00 | 5.38±1.17h | 5.00 | ||||
| Poor | 17 (6.9) | 0.47±0.72f | 0.00 | 5.00±1.46 | 5.00 | 6.76±0.44 | 7.00 | 6.29±0.77gh | 6.00 | ||||
| AJCC pathological stage | |||||||||||||
| I, II | 167 (67.9) | 1.17±1.16 | 1.00 | 0.856* | 4.65±1.41 | 5.00 | 0.428* | 6.57±0.66 | 7.00 | 0.071† | 5.43±1.19 | 5.00 | 0.787* |
| III, IV | 79 (32.1) | 1.20±1.18 | 1.00 | 4.81±1.54 | 5.00 | 6.72±0.58 | 7.00 | 5.47±1.13 | 6.00 | ||||
| T classification | |||||||||||||
| T1, T2 | 194 (78.9) | 1.21±1.17 | 1.00 | 0.461* | 4.70±1.41 | 5.00 | 0.878* | 6.61±0.64 | 7.00 | 0.517* | 5.45±1.19 | 5.50 | 0.706* |
| T3, T4 | 52 (21.1) | 1.08±1.17 | 1.00 | 4.73±1.62 | 5.00 | 6.67±0.62 | 7.00 | 5.38±1.11 | 6.00 | ||||
| N classification | |||||||||||||
| N0 | 195 (79.3) | 1.14±1.13 | 1.00 | 0.302* | 4.70±1.43 | 5.00 | 0.902* | 6.57±0.66 | 7.00 | 0.017† | 5.38±1.19 | 5.00 | 0.154* |
| N1, N2 | 51 (20.7) | 1.33±1.31 | 1.00 | 4.73±1.55 | 5.00 | 6.80±0.49 | 7.00 | 5.65±1.07 | 6.00 | ||||
Abbreviations: AJCC, American Joint Committee on Cancer.
*p values were estimated by student’s T test.
†p values were estimated by Mann-Whitney U test.
‡ p values were estimated by 1-way ANOVA test.
§p values were estimated by Kruskal-Wallis 1-way ANOVA test.
ap = 0.003;
bp = 0.021;
cp = 0.032;
dp = 0.026;
ep<0.001;
fp = 0.007;
gp = 0.024;
hp = 0.008.