Table 3. The expression levels of cleaved caspase-3 (CC-3), caspase-3 (C-3), caspase-8 (C-8) and caspase-9 (C-9) for disease-specific survival and disease-free survival of OTSCC patients.
| Variable | Disease-specific survival | Disease-free survival | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. (%) | CHR (95% CI) | p value | AHR (95% CI) | p value* | CHR (95% CI) | p value | AHR (95% CI) | p value† | ||
| CC-3 expression | Negative | 95 (38.6) | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| Positive | 151 (61.4) | 1.06 (0.72–1.56) | 0.765 | 1.04 (0.70–1.54) | 0.848 | 1.57 (1.02–2.41) | 0.041 | 1.54 (1.00–2.40) | 0.053 | |
| C-3 expression | Low | 88 (35.8) | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| High | 158 (64.2) | 0.86 (0.58–1.27) | 0.448 | 0.74 (0.49–1.10) | 0.134 | 1.06 (0.70–1.61) | 0.781 | 1.07 (0.70–1.63) | 0.760 | |
| C-8 expression | Low | 72 (29.3) | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| High | 174 (70.7) | 1.14 (0.76–1.72) | 0.532 | 0.98 (0.65–1.49) | 0.930 | 1.01 (0.65–1.56) | 0.963 | 0.94 (0.61–1.46) | 0.787 | |
| C-9 expression | Low | 119 (48.4) | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| High | 127 (51.6) | 1.01 (0.69–1.47) | 0.954 | 0.90 (0.61–1.33) | 0.593 | 1.19 (0.80–1.78) | 0.391 | 1.19 (0.79–1.79) | 0.418 | |
Abbreviations: CHR, crude hazard ratio; CI, confidence interval; AHR, adjusted hazard ratio.
*p-value were adjusted for cell differentiation(moderate, poor vs. well), AJCC pathological stage (stage II, III, IV vs stage I), postoperative RT by multiple Cox‘ s regression.
†p-value were adjusted for cell differentiation(moderate, poor vs. well), AJCC pathological stage (stage II, III, IV vs stage I) by multiple Cox‘ s regression.