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. 2017 Jul 10;12(7):e0180650. doi: 10.1371/journal.pone.0180650

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© 2017 Chaisawang et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — Mean exploration times (mean ± SEM) of animals during the familiarization (A) and choice (B) trials of the NOL test after treatment. In the familiarization trial, animals from all groups showed no significant difference in the total exploration time of the two objects (p>0.05). In the choice trial, the control, AA, 5-FU+AA (preventive), and 5-FU+AA (throughout) groups spent significantly longer exploring the object in the novel location compared with that in the familiar location (*p<0.05), whereas the 5-FU and 5-FU+AA (recovery) groups did not (p>0.05).