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Blood oxygenation level-dependent (BOLD) signal response for left insula in constipation-predominant irritable bowel syndrome (IBS-C), diarrhea-predominant irritable bowel syndrome (IBS-D) patients, and healthy controls. Gray, black, red, and blue bars represent the rest (balloon volume kept at 0 mL), inflation, active (balloon volume kept at pain threshold), and deflation periods, respectively.
