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. 2017 Jul 1;23(3):415–427. doi: 10.5056/jnm16148

Table 2.

Brain Regions Significantly Activated During Rectal Pain Compared with Baseline (z Score > 3) in Constipation-predominant Irritable Bowel Syndrome, Diarrhea-predominant Irritable Bowel Syndrome Patients and Healthy Controls

Anatomical description Hemisphere No. of voxels Peak intensity Z-score MNI co-ordinates
x y z
IBS-C
 Supramarginal gyrus L 17 5.84 4.59 −63 −43 31
 Insula L 65 5.53 4.43 −42 14 4
 Mid cingulate cortex R 87 5.73 4.54 6 −13 49
 Supplementary motor area R 18 5.37 4.34 6 −1 64
 Middle temporal gyrus L 15 5.29 4.30 −60 −28 −11
IBS-D
 Supramarginal gyrus L 15 5.76 4.55 −60 −46 28
 Insula L 470 7.15 5.23 −42 14 1
 Supplementary motor area R 67 7.07 5.20 6 5 64
 Inferior orbitofrontal cortex L 64 6.39 3.52 −33 32 −8
 Middle temporal gyrus R 24 5.55 4.44 57 −37 1
 Middle temporal gyrus L 107 6.23 4.79 −54 −25 −2
 Cerebellum_6 L 258 7.43 5.34 −24 −61 −23
 Cerebellum crus I L 25 5.89 4.62 −24 −88 −23
 Fusiform gyrus L 24 6.15 4.76 −39 −52 −23
 Fusiform gyrus R 20 6.05 4.71 36 −82 −17
Healthy controls
 Supramarginal gyrus L 12 5.02 4.14 −60 −34 25
 Supplementary motor area R 45 5.60 4.47 6 4 64
 Cerebellum crus I L 11 6.41 4.88 −12 −85 −23
 Precuneus/superior parietal lobule R 79 5.89 4.62 6 −52 61
 Precuneus/superior parietal lobule L 17 5.26 4.27 −18 −61 58

MNI, Montreal Neurological Institute; L, left; R, right; IBS-C, constipation-predominant irritable bowel syndrome; IBS-D, diarrhea-predominant irritable bowel syndrome.

x, y, and z correspond to the coordinates of the activated clusters. Z is the Z score equivalent of the activated cluster (P < 0.05, corrected for multiple comparisons [family wise error rate], spatial extent k = 10 voxels).