Table 2.
Significantly (q < 0.1) Mutated Genes in Ampullary Carcinomas (n = 172)
| Gene | Frequency (%) | Patients | Number of inactivating alteration | p value | q value | |
|---|---|---|---|---|---|---|
| 1 | KRAS | 47.7 | 82 | 0 | 1.14E-118 | 1.06E-116 |
| 2 | TP53 | 55.8 | 96 | 30 | 5.88E-117 | 2.73E-115 |
| 3 | CTNNB1 | 23.3 | 40 | 1 | 2.71E-22 | 8.40E-21 |
| 4 | SMAD4 | 16.3 | 28 | 10 | 4.37E-16 | 1.02E-14 |
| 5 | APC | 33.7 | 58 | 54 | 1.89E-14 | 3.52E-13 |
| 6 | ELF3 | 12.2 | 21 | 17 | 1.15E-11 | 1.78E-10 |
| 7 | GNAS | 11.6 | 20 | 1 | 5.58E-08 | 7.41E-07 |
| 8 | ACVR2A | 7.6 | 13 | 9 | 1.34E-05 | 0.000147192 |
| 9 | ERBB3 | 10.5 | 18 | 0 | 1.42E-05 | 0.000147192 |
| 10 | ACVR1B | 8.1 | 14 | 5 | 4.60E-05 | 0.000428017 |
| 11 | ARID2 | 15.7 | 27 | 21 | 5.68E-05 | 0.000479964 |
| 12 | BRAF | 9.3 | 16 | 0 | 0.00013007 | 0.00100804 |
| 13 | CDKN2A | 4.7 | 8 | 5 | 0.000227549 | 0.00162785 |
| 14 | TGFBR1 | 6.4 | 11 | 3 | 0.000609132 | 0.00404637 |
| 15 | SOX9 | 8.1 | 14 | 12 | 0.000876341 | 0.00543331 |
| 16 | LOXHD1 | 11 | 19 | 0 | 0.00128913 | 0.00749306 |
| 17 | ERBB2 | 11.6 | 20 | 0 | 0.00165826 | 0.00907168 |
| 18 | FBXW7 | 5.8 | 10 | 3 | 0.00254902 | 0.01317 |
| 19 | EPHA3 | 7 | 12 | 2 | 0.005577 | 0.027298 |
| 20 | EPHA6 | 5.8 | 10 | 0 | 0.0059163 | 0.0275108 |
| 21 | TGFBR2 | 5.8 | 10 | 3 | 0.0110298 | 0.0466613 |
| 22 | RNF43 | 7 | 12 | 9 | 0.0110381 | 0.0466613 |
| 23 | CNTN4 | 7 | 12 | 2 | 0.0154074 | 0.0622994 |
| 24 | SLITRK5 | 8.1 | 14 | 2 | 0.0255168 | 0.0988775 |