Table 3.

Mutation Frequencies of Significantly Mutated Genes in Intestinal-type Ampullary Carcinomas versus Colorectal Carcinomas and Pancreatobiliary-type Carcinomas versus Pancreatic Carcinomas

	Intestinal-type ampullary carcinomas	Colorectal carcinomas (TCGA)	Pancreatobiliary-type ampullary carcinomas	Pancreatic carcinomas (Biankin et al., 2012)
1	APC (50%)	APC (81%)	KRAS (68%)	KRAS (99%)
2	TP53 (46%)	TP53 (60%)	TP53 (67%)	TP53 (33%)
3	KRAS (39%)	KRAS (43%)	SMAD4 (20%)	SMAD4 (16%)
4	CTNNB1 (26%)	TTN (31%)	CTNNB1 (15%)	MLL3 (7%)
5	ARID2 (18%)	PIK3CA (18%)	ERBB3 (14%)	ATM (5%)
6	ERBB2 (14%)	FBXW7 (11%)	GNAS (12%)	NALCN (5%)
7	ACVR2A (13%)	SMAD4 (10%)	CDH10 (12%)	ARID1A (4%)
8	SMAD4 (13%)	NRAS (9%)	ELF3 (11%)	SF3B1 (4%)
9	GNAS (13%)	TCF7L2 (9%)	CDKN2A (9%)	TGFBR2 (4%)
10	SOX9 (13%)	FAM123B (7%)		ARID2 (3%)