Table 1.
Baseline characteristics by donor age.
| Variable | Overall | Age 20 or Younger | Age 21–50 | Age 50–59 | Age 60 or Older | P-value |
|---|---|---|---|---|---|---|
| N | 11,835 | 2553 (21.6%) | 7072 (59.8%) | 1738 (14.7%) | 472 (4.0%) | |
| Recipient Characteristics | ||||||
| Age (years) | 59 (50, 64) | 58 (47, 64) | 58 (49, 64) | 60 (52, 65) | 62 (56, 65) | < 0.001 |
| Female | 4,818 (40.7%) | 1,008 (39.5%) | 2,810 (39.7%) | 769 (44.2%) | 231 (48.9%) | < 0.001 |
| Race/Ethnicity | 0.226 | |||||
| White/Caucasian | 9,937 (84.0%) | 2,151 (84.3%) | 5,931 (83.9%) | 1,437 (82.7%) | 418 (88.6%) | |
| Black/African-American | 1,017 (8.6%) | 218 (8.5%) | 619 (8.8%) | 153 (8.8%) | 27 (5.7%) | |
| Hispanic | 644 (5.4%) | 136 (5.3%) | 377 (5.3%) | 111 (6.4%) | 20 (4.2%) | |
| Other | 237 (2.0%) | 48 (1.9%) | 145 (2.1%) | 37 (2.1%) | 7 (1.5%) | |
| Etiology of Lung Disease | < 0.001 | |||||
| Obstructive Lung Disease | 4,028 (34.0%) | 821 (32.2%) | 2,402 (34.0%) | 608 (35.0%) | 197 (41.7%) | |
| Restrictive Lung Disease | 5,972 (50.5%) | 1,287 (50.4%) | 3,530 (49.9%) | 914 (52.6%) | 241 (51.1%) | |
| Cystic Fibrosis/Immunodeficiency | 1,455 (12.3%) | 361 (14.1%) | 906 (12.8%) | 167 (9.6%) | 21 (4.4%) | |
| Other | 380 (3.2%) | 84 (3.3%) | 234 (3.3%) | 49 (2.8%) | 13 (2.8%) | |
| Hypertension | 439 (3.7%) | 114 (4.5%) | 245 (3.5%) | 61 (3.5%) | 19 (4.0%) | 0.133 |
| Diabetes | 2,098 (17.9%) | 429 (16.9%) | 1,265 (18.0%) | 323 (18.7%) | 81 (17.3%) | 0.468 |
| Body Mass Index (kg/m2) | 25 (22, 29) | 25 (21, 28) | 25 (22, 29) | 25 (22, 28) | 26 (22, 28) | 0.001 |
| Steroid Treatment (Pre-Op) | 5,324 (46.5%) | 1,100 (44.5%) | 3,192 (46.7%) | 810 (48.0%) | 222 (48.2%) | 0.105 |
| Recipient Smoking History | 7,199 (60.8%) | 1,495 (58.6%) | 4,280 (60.5%) | 1,107 (63.7%) | 317 (67.2%) | < 0.001 |
| Creatinine at Time of Transplant | 0.8 (0.7, 1) | 1 (1, 1) | 1 (1, 1) | 1 (1, 1) | 1 (1, 1) | 0.540 |
| Functional Status at Transplant | 0.114 | |||||
| ADL With No Assistance | 3,541 (29.9%) | 793 (31.1%) | 2,098 (29.7%) | 528 (30.4%) | 122 (25.8%) | |
| ADL With Assistance | 4,774 (40.3%) | 1,046 (41.0%) | 2,856 (40.4%) | 687 (39.5%) | 185 (39.2%) | |
| Disabled/Hospitalized | 3,344 (28.3%) | 673 (26.4%) | 2,014 (28.5%) | 502 (28.9%) | 155 (32.8%) | |
| LAS at Match | 40 (35, 49) | 39 (35, 49) | 40 (35, 49) | 39 (35, 49) | 38 (34, 47) | 0.106 |
| O2 Requirement at Rest | 3 (2, 4) | 3 (2, 4) | 3 (2, 4) | 3 (2, 4) | 3 (2, 4) | 0.399 |
| Six Minute Walk Distance (ft) | 820 (459, 1,138) | 808 (449, 1,154) | 820 (467, 1,125) | 908 (500, 1,176) | 760 (458, 1,070) | 0.598 |
| Known History of Malignancy | 838 (7.1%) | 165 (6.5%) | 498 (7.1%) | 127 (7.3%) | 48 (10.2%) | 0.037 |
| Known to be Working at time of Transplant | 1,144 (10.0%) | 272 (11.1%) | 693 (10.2%) | 141 (8.4%) | 38 (8.5%) | 0.021 |
| Donor Characteristics | ||||||
| Donor PO2 on 100% O2 (mmHg) | 421 (242, 492) | 434 (228, 505) | 417 (238, 489) | 413 (275, 485) | 423 (286, 500) | 0.023 |
| Donor Diabetes | 804 (6.8%) | 27 (1.1%) | 406 (5.8%) | 281 (16.2%) | 90 (19.1%) | < 0.001 |
| Operative Characteristics | ||||||
| Bilateral Transplant | 7,775 (65.7%) | 1,697 (66.5%) | 4,625 (65.4%) | 1,159 (66.7%) | 294 (62.3%) | 0.246 |
| Ischemic Time (hours) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 0.175 |
| Time on Waiting List (days) | 72 (21, 226) | 82 (24, 236) | 70 (20, 220) | 70 (20, 230) | 69 (18, 243) | 0.077 |
| Center Volume (# of Cases in Study Period) | 577 (373, 874) | 542 (373, 829) | 574 (373, 874) | 653 (406, 1,201) | 752 (450, 1,201) | < 0.001 |
*
ADL – Activities of Daily Living. LAS – Lung Allocation Score. Continuous variables are presented as median (interquartile range) while categorical variables are presented as frequency (percentage).