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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: J Immunol. 2017 May 26;199(1):336–347. doi: 10.4049/jimmunol.1502181

Figure 9. Donor effector T cells are significantly increased in CD70-/- hosts.

Figure 9

WT or CD70-/- C57BL/6 mice received 965 cGy irradiation on day -1 and were subsequently transplanted day 0 with 4×106 BALB/c BM + 5×106 PanT. On day 5 post allo-HCT mice were injected with 250μg of BFA. 6 hrs post-injection mice were sacrificed, spleens were harvested and assessed for IFN-γ production by flow cytometry. (A) Depicted is IFN-γ expression within live H-2Kd+CD4+ and live H-2Kd+CD8+ T cells. (B) The percentage and absolute numbers of donor CD4+ and CD8+ producing IFN-γ. Representative data from one of two individual experiments is shown. Data were analyzed by student's t test. **P<0.01.