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The characterization of HDDN.
Notes: (A) The DNA retardation assay of HDDN at various weight ratios of HA to DNA: 1) DNA; 2) DDN; 3) 20:8; 4) 30:8; 5) 40:8; 6) 50:8; 7) 60:8; 8) 70:8; 9) 80:8. (B and C) Size distribution and morphology of HDDN.
Abbreviations: DDN, doxorubicin-4-hydrazinobenzoic acid-polyethyleneimine conjugate/DNA nanoparticles; HA, hyaluronic acid; HDDN, hyaluronic acid-shielded pH and enzyme dual-responsive nanoparticles.
