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. 2017 Jul 4;12:4773–4788. doi: 10.2147/IJN.S134378

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© 2017 Wang et al. This work is published and licensed by Dove Medical Press Limited

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Stability of HDDN in serum, DNase I and Hyals.

Notes: (A) The changes in size and zeta potential of HDDN incubated with different concentrations of Hyals (0 and 120 units/mL) for 1 h. The lines and the columns represent the changes in zeta potential and size, respectively. (B) The stability of HDDN in the presence or absence of 20% serum for 24 h. The lines and the columns represent the changes in zeta potential and size, respectively. (C and D) The stability of DDN and HDDN after incubation with DNase I for 12 h.

Abbreviations: DDN, doxorubicin-4-hydrazinobenzoic acid-polyethyleneimine conjugate/DNA nanoparticles; HDDN, hyaluronic acid-shielded pH and enzyme dual-responsive nanoparticles; Hyals, hyaluronidases.