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Co-localization of CD44 and HDDN in CD44-positive cells at different time points after incubation with HDDN.
Notes: In the figure at 0.5, 1 and 2 h, the white arrows indicated the co-localization of CD44 and HDDN. While in the figure at 4 h, the white arrows indicate the co-localization of DOX and nucleus.
Abbreviations: DOX, doxorubicin; HDDN, hyaluronic acid-shielded pH and enzyme dual-responsive nanoparticles.
