Table S1.
Significant taxa between COPD and controls at different taxonomic levels
| Significant taxa* | Control | COPD | Raw P-value | FDR |
|---|---|---|---|---|
| Class | ||||
| Bacilli | 9.20 (6.02–17.68) | 4.87 (1.96–8.53) | 0.008 | 0.091 |
| Negativicutes | 5.38 (2.26–10.75) | 10.07 (4.90–13.89) | 0.027 | 0.163 |
| Spirochaetes | 0.07 (0.04–0.23) | 0.02 (0.00–0.11) | 0.050 | 0.19 |
| Order | ||||
| Lactobacillales | 9.03 (5.80–17.43) | 4.85 (1.91–8.41) | 0.008 | 0.151 |
| Selenomonadales | 5.38 (2.26–10.75) | 10.07 (4.90–13.89) | 0.027 | 0.173 |
| Bacillales | 0.20 (0.12–0.38) | 0.11 (0.03–0.29) | 0.024 | 0.173 |
| Family | ||||
| Veillonellaceae | 5.38 (2.26–10.75) | 10.07 (4.90–13.86) | 0.028 | 0.171 |
| Streptococcaceae | 9.01 (5.79–17.40) | 4.83 (1.91–8.25) | 0.008 | 0.171 |
| Spirochaetaceae | 0.07 (0.04–0.23) | 0.02 (0.00–0.11) | 0.050 | 0.177 |
| Porphyromonadaceae | 2.91 (1.28–4.19) | 1.07 (0.08–4.89) | 0.043 | 0.171 |
| Clostridiales_Incertae_Sedis_XI | 0.01 (0.00–0.04) | 0.00 (0.00–0.00) | 0.026 | 0.171 |
| Bacillales_Incertae_Sedis_XI | 0.20 (0.12–0.38) | 0.11 (0.03–0.24) | 0.022 | 0.171 |
| Genus | ||||
| Veillonella | 4.78 (2.19–9.95) | 8.76 (4.64–13.43) | 0.030 | 0.163 |
| Streptococcus | 9.01 (5.79–17.39) | 4.83 (1.91–8.25) | 0.008 | 0.094 |
| Streptobacillus | 0.00 (0.00–0.03) | 0.00 (0.00–0.00) | 0.001 | 0.031 |
| Porphyromonas | 2.87 (1.22–4.05) | 0.98 (0.06–4.23) | 0.031 | 0.163 |
| Parvimonas | 0.00 (0.00–0.03) | 0.00 (0.00–0.00) | 0.048 | 0.197 |
| Leptotrichia | 0.82 (0.36–1.26) | 1.34 (0.59–4.05) | 0.034 | 0.163 |
| Gemella | 0.20 (0.12–0.38) | 0.11 (0.03–0.24) | 0.022 | 0.163 |
| Filifactor | 0.03 (0.00–0.14) | 0.00 (0.00–0.02) | 0.003 | 0.051 |
| OTU (species level) | ||||
| otu3 (Veillonella_dispar) | 4.73 (2.10–9.89) | 8.52 (4.63–13.10) | 0.035 | 0.176 |
| otu4 (Streptococcus_unclassified) | 6.02 (4.77–10.99) | 2.46 (0.70–5.83) | 0.003 | 0.034 |
| otu9 (Leptotrichia_unclassified) | 0.12 (0.03–0.57) | 0.54 (0.13–0.99) | 0.041 | 0.177 |
| otu10 (Prevotella_nanceiensis) | 0.73 (0.43–1.58) | 0.16 (0.02–0.78) | 0.003 | 0.034 |
| otu22 (Pasteurellaceae_unclassified) | 0.07 (0.02–0.57) | 0.01 (0.00–0.09) | 0.025 | 0.153 |
| otu26 (Gemella_unclassified) | 0.20 (0.13–0.38) | 0.11 (0.03–0.24) | 0.023 | 0.153 |
| otu28 (Porphyromonas_endodontalis) | 0.23 (0.12–0.47) | 0.06 (0.00–0.21) | 0.002 | 0.034 |
Notes:
*
Significant taxa: both raw P<0.05 calculated by Mann–Whitney U-test and FDR <0.2. Value of relative abundance was represented via “median (interquartile range).”
Abbreviations: FDR, false discovery rate; OTU, operational taxonomic unit.