Table 4.

Chemo-informatics evaluation of the synthesized compounds

Properties	4a	4b	4c	4d	4e	6a	6b	6c	6d	6e
MW	327	327	343	343	343	337	353	353	369	371
HBA	4	4	5	5	5	3	4	4	5	3
HBD	2	2	3	3	3	1	2	2	3	1
Log P	2.8	3.8	3.4	3.4	3.5	4.8	4.4	4.5	4.1	4.5
PSA	61	61	77	76	78	42	59	60	77	42
MV	328	328	339	341	339	361	372	372	382	378
Drug score	1.09	1.11	1.41	1.30	0.85	0.35	0.42	0.68	0.69	0.83
RO5	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes

Abbreviations: MW, molecular weight (g/mol); HBA, hydrogen bond acceptor; HBD, hydrogen bond donor; Log P, lipophilicity of partition coefficient; PSA, polar surface area; MV, molar volume (A³); RO5, rule of five.