Appendix 1—figure 1. Crystallographic structure of hnRNP A1 RRMs (UP1) bound to telomeric DNA repeats.
In this structure, one single-stranded DNA molecule consisting of 2 repeats of the TTAGGG motif is bound by two distinct UP1 molecules (one in red, one in blue) that are related by a crystallographic symmetry (C2 axis pointing perpendicular to the plan of the figure). RRM1 binds the 5´ end of the DNA and RRM2 the 3´ end. The inter-RRM linker (residues 89 to 105) is in yellow. PDB ID code 2UP1 (Ding et al., 1999).