Figure 1. Magnesium treatment improves the stiffened joints phenotype in asj mice at 14 weeks of age.

The asj mice on control diet (group B) develop stiffening of the joints leading to contractures as shown on the front paws (arrows) in comparison with a corresponding wild type mouse (group A). The asj mice on high magnesium diet whose mothers were also placed on the same diet during pregnancy and nursing had improved phenotype of stiffening of the joints in the front paws (group E).